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&&&&Effect of L-Arginine on cardiac damage induced by isoproterenol
&&&&L-精氨酸对异丙肾上腺素致害心肌的影响
&&&&Pretreatment with prostaglandin E_1 attenuates myocardial
injury caused by isoproterenol
&&&&前列腺素E_1预处理对异丙肾上腺素性心肌损伤的保护作用
&&&&Effects of magnesium fructose-1,6-diphosphate on myocardial
lesion induced by isoproterenol in rats
&&&&1,6-二磷酸果糖镁对异丙肾上腺素所致大鼠心肌损伤的保护作用
&&&&Amelioration of(7S,13R)-CPU86017 and CPU0213 on Damage to Vascular Activity Induced by Isoproterenol in Rats
&&&&(7S,13R)-CPU86017及CPU0213对异丙肾上腺素损害血管活性的改善作用
&&&&Study of Preventive Effects of Bisoprolol on Myocardiac Necrosis, Fibrosis and Expression of Apoptosis Related Gene in Rats Injured by Isoproterenol
&&&&比索洛尔对异丙肾上腺素引起的大鼠心肌坏死、纤维化和细胞凋亡相关基因表达的干预研究
&&&&ANTAGONISTIC EFFECTS OF ISOPRENALINE ON 15-METHYL-PROSTAGLANDIN F_(2α)-INDUCED ABORTION IN MICE
&&&&异丙肾上腺素对15-甲基前列腺素F_(2α)致小鼠流产的拮抗作用
&&&&The influence of beta-receptor blockers on the effect of heart muscle oxygen consumptions induced by isoprenaline
&&&&β受体阻断剂对异丙肾上腺素提高心肌耗氧量作用的影响
&&&&EFFECT OF BETA ADRENOCEPTOR AGONIST, ISOPRENALINE, ON cAMP LEVELS IN MOUSE UTERUS
&&&&β受体激动剂异丙肾上腺素对小鼠子宫cAMP水平的影响
&&&&EFFECTS OF NEFERINE ON PHYSIOLOGIC PROPERTIES AND THE DOSE-EFFECT RESPONSE OF ISOPRENALINE AND Ca~(2+) IN GUINEA PIG ATRIA
&&&&甲基莲心碱对豚鼠心房生理特性及异丙肾上腺素和Ca~(2+)量—效反应的影响
&&&&Methods: To observe the effects of adrenaline,noradrenaline,isoprenaline and phentolamine on the blood pressure of rats and rabbits.
&&&&方法:利用直接测定血压方法观察肾上腺素(AD)、去甲肾上腺素(NA)、异丙肾上腺素(ISP)、酚妥拉明分别对大鼠及家兔血压有何影响。
&&&&Methods: The relaxation effect of SPFF on isolated tracheal strip of guinea pigs,and its positive chronotropic effect on isolated left atria of guinea pigs were studied by comparison with isoprenaline hydrochloride. The antagonist effect of ICI 118551 on SPFF was also studied by using isolated tracheal strip of guinea pigs.
&&&&方法:以盐酸异丙肾上腺素为对照考察SPFF对离体豚鼠气管条的松弛作用,及对离休豚鼠左心房的正性变时作用,并使用离体气管条考察特异性β_2受体阻滞剂ICI 118551对SPFF的拮抗作用。
&&&&Results:The relaxation effect of SPFF on isolated tracheal strip of guinea pigs was comparative to that of isoprenaline hydrochloride, and could be competitively antagonized by ICI 118551. The positive chronotropic effect of SPFF on isolated left atria of guinea pigs was 60 % of that of isopreneline hydrochloride. And the selectivity of SPFF on β2 adrenoeceptor was 163 times to that of isoprenaline hydrochloride.
&&&&结果:SPFF对离休豚鼠气管条的松弛作用与异丙肾上腺素相当,且这一作用可被ICI 118551竞争性拮抗,而SPFF对离体豚鼠左心房的正性变时效应为异丙肾上腺素的60％,SPFF对β_2受体的选择性是异丙肾上腺素的163倍。
&&&&The protective effect of SPFF on induced asthma in guinea pigs was 7 times stronger than that of salbutamol and the binding property of SPFF to β adrenoreceptor in isolated lung tissue was respectively 4 times and 200 times of that of isoprenaline hydrochloride and salbutamol. The enhanced effect of SPFF on cAMP level in isolated lung tissue of rats was 3 times that of salbutamol.
&&&&SPFF对药物引起豚鼠喘息的保护作用比沙丁胺醇强约7倍,对肺内β受体的结合能力分别是异丙肾上腺素的4倍和沙丁胺醇的约200倍,而对肺组织内cAMP的升高作用约相当于同剂量沙丁胺醇的3倍。
&&&&The protective effect of peptide 6A on isoproterenol-induced myocardial damage in rat
&&&&肽6A对大鼠异丙肾上腺素心肌损伤的治疗作用
&&&&Protective Effects of Bovine Blood Superoxide Dismutase on Isoprenaline-Induced Myocardial Ischemia in Rats
&&&&牛血超氧化物歧化酶对异丙肾上腺素诱导的心肌缺血的保护作用
&&&&Objective: To study the intervention of(7S,13R)CPU86017 and CPU0213 on isoproterenol-induced damage to vascular function.
&&&&目的:探讨具有钙拮抗及抗氧化作用的(7S,13R)-CPU86017及内皮素受体拮抗剂CPU0213对异丙肾上腺素诱导的血管功能损伤的改善作用。
&&&&Study on the Signal Transmit Mechanism of
β-acceptor Agonist-Isoprenaline
Regulating Sinus P-cell Delayed Rectifier Potassium Channels
&&&&异丙肾上腺素调节窦房结起搏细胞延迟整流钾通道信号传递机制的研究
&&&&Nuclear Ca~(2+)
transport of isoprenaline-induced heart hypertrophy in rats
&&&&异丙肾上腺素致大鼠心肌肥厚时心肌细胞核Ca~(2+)转运
查询“异丙肾上腺素”译词为用户自定义的双语例句&&&&我想查看译文中含有：的双语例句
为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法，我们为您准备了出自英文原文的大量英语例句，供您参考。&&&&&&&&&&&&&&&&&&&&&&&& The present paper describes the effect of extractum of root Pueraria pseudo-hirsuta (Erpph) on the β-adrenergic receptor of various tissues of animals. The results showed that this extract had potent β-adrenergic receptor blocking effects. There is evidence that its blocking action on β_1-receptors is stronger than on β_2-receptors.It was found that at the dosage of 0.5～5 mg/ml or 750 mg/kg Erpph could antagonize the heart excitation induced by isoproterenol (0.17～1.7μg/ml or 10 μg/kg) in vivo and in vitro respectively.... The present paper describes the effect of extractum of root Pueraria pseudo-hirsuta (Erpph) on the β-adrenergic receptor of various tissues of animals. The results showed that this extract had potent β-adrenergic receptor blocking effects. There is evidence that its blocking action on β_1-receptors is stronger than on β_2-receptors.It was found that at the dosage of 0.5～5 mg/ml or 750 mg/kg Erpph could antagonize the heart excitation induced by isoproterenol (0.17～1.7μg/ml or 10 μg/kg) in vivo and in vitro respectively. Erpph was also found to block the depressor reaction of the vessels by injection of isoproterenol (10/μg/kg) and adrenalin (10μg/kg) but it has no effect on the pressor reaction to nor-adrenalin (10 μg/kg). On the other hand, Erpph (750 mg/kg)was shown to decrease the resting heart rate and blood pressure (average 43.7％ or average 40±6 mmHg, respectively). These facts form a theoretical bssis for using Erpph in angina pectoris, arrhythmia and hypertension.By comparing the effect of this extractum (750 mg/kg) and practolol (0.1 mg/kg) it was also found that they had almost the same β-adrenergic blocking effect, but the former was stronger to depress the blood pressure and the latter was stronger to depress the heart rateFrom these studies, it is concluded that Erpph is a potent and safe β-blocker.本文报告了葛根浸膏具有较为广泛而显著的β-受体阻滞效应。且对β_1-受体的作用强于β_2-受体。 相当于0.5～5mg/ml或750mg/kg的葛根能分别对抗异丙肾上腺素0.17～1.7μg/ml或10μg/kg诱发的离体或在体心脏的兴奋作用。此外,相当于750mg/kg的葛根除能阻滞10μg/kg异丙肾上腺素及肾上腺素舒血管(β-受体效应)所致的降压作用外,尚能降低正常心率(平均下降43.7％)及血压(平均下降40±6mmHg)的作用,这些结果为葛根用来缓解心绞痛,治疗快速型心律失常及高血压等提供了根据。 将葛根(750mg/kg)与心得宁(0.1mg/kg)抗异丙肾上腺素(10μg/kg)所致的β-受体效应加以比较,表明两者作用大体相似,减慢心率的作用心得宁似乎稍强于葛根。降压作用葛根略优于心得宁,且葛根无明显的抑制心脏的作用。 根据上述事实,可以认为葛根是一种有效的β-受体阻滞剂。 Heart rhythm disturbances were precipitated in about 80.9% of normal rabbits 0～10 minutes after the intravenous injection of pyquiton at the dosage of 35～45 mg/kg, and sustained for 1～21 minutes. Prior to cardiac arrhythmia, bradycardia was observed in 84.1% of the rabbits. Among the tested antiarrhythmic agents, phenoxybenzamine (dibenzyline) at the dosage of 3 mg/kg exhibited the most dramatic antiarrhythmic action on pyquiton- chlorpromazine hydrochloride (5mg/kg), isoptinum (0.3～0.5 mg/kg),... Heart rhythm disturbances were precipitated in about 80.9% of normal rabbits 0～10 minutes after the intravenous injection of pyquiton at the dosage of 35～45 mg/kg, and sustained for 1～21 minutes. Prior to cardiac arrhythmia, bradycardia was observed in 84.1% of the rabbits. Among the tested antiarrhythmic agents, phenoxybenzamine (dibenzyline) at the dosage of 3 mg/kg exhibited the most dramatic antiarrhythmic action on pyquiton- chlorpromazine hydrochloride (5mg/kg), isoptinum (0.3～0.5 mg/kg), promethazine hydrochloridum(3～5 mg/kg) and phenytoine sodium (50 mg/kg) could als lidocaine hydrochloride, quinidine, isopreanline sulfate, and atropine sulfate etc. showed partial and/ or incomplete while proctolol and shangrolin were ineffective. Preadministration of phenytoine sodium (50 mg/kg), chlorpromazine hydrochloride (5 mg/kg) etc. were demonstrated to be effective in preventing the pyquitoninduced arrhythmia.家兔静脉注射吡喹酮35～45mg/kg后10分钟内,80.9％(17/21)的兔发生心律失常,持续1～21分钟后恢复窦性心律。心律失常出现前心率较正常时缓慢的占84.1％(58/69)。抗心律失常药中,以酚苄明3mg/kg对抗吡喹酮所致心律失常转为窦性心律的作用最好,其次为氯丙嗪(5mg/kg)、异搏停(0.3～0.5mg/kg)、异丙嗪(3～5mg/kg)及苯妥因钠(50mg/kg),利多卡因、奎尼丁、异丙肾上腺素与阿托品等有部分或作用不完全的抗心律失常的效果。心得宁与常咯啉则无效。先给兔注射苯妥因钠(50mg/kg)或氯丙嗪(5mg/kg)等,有较好的防止吡喹酮所致心律失常的作用。 Asatum heterotropoides (A. H) was shown to improve the left ventricular pump function and myocardial contractility in dogs.After an intravenous injection of A.H at a dose of 0.1～0.4ml(1:2)/kg in the dog heart-lung preparation (HLP), the results were as follows: LVSP↑, LVEDP↓, MAP↑, CO↑, HR↑, SV↓, dp/dt max↑, -dp/dt max↑, t-dp/dt max↓, Vpm↑, Vce-cpip↑, Vmax↑, After an intravenous injection of A.H at a dose of 0.05～0.4 ml (1:2)/kg in anesthetized open-chest dogs, with exception of MAP↑, and SV↑, similar resulte... Asatum heterotropoides (A. H) was shown to improve the left ventricular pump function and myocardial contractility in dogs.After an intravenous injection of A.H at a dose of 0.1～0.4ml(1:2)/kg in the dog heart-lung preparation (HLP), the results were as follows: LVSP↑, LVEDP↓, MAP↑, CO↑, HR↑, SV↓, dp/dt max↑, -dp/dt max↑, t-dp/dt max↓, Vpm↑, Vce-cpip↑, Vmax↑, After an intravenous injection of A.H at a dose of 0.05～0.4 ml (1:2)/kg in anesthetized open-chest dogs, with exception of MAP↑, and SV↑, similar resulte were obtained (LVSP↑, LVEDP↓, CO↑, HR↑, dp/dt max↑,-dp/dt max↑, t-dp/dt max↑, Vpm↑, Vce-cpip↑, Vmax↑). In the two experiments, positive down curve of Lissajous figure were removed to the right up position.Since the HLP is devoid of inferences of the pre-and after-load of the heart, the increase of pump function by A. H seems to be the result of direct action on myocardial contractility.The result of A. H on cardiac functions and hemodynamics in comparison with Higenamine (H. G) and Isoprenaline (I. S) showed that all drugs increased the left ventricle function. The only difference was that A. H increased SV and H. G、I. S decreased SV. The difference could attribute to the effect of A. H to heart rate that make the increase of heart rate in more proper level than the other two agents.After β-Adrenergic blockade, the effect of A. H on the elevation of CO was unchanged.实验表明细辛可使狗左室泵功能和心肌收缩性能明显改善。在心肺制备狗,主要表现为LVSP↑,LVEDP↓,MAP↑,CO↑,HR↑,SV↓,dp/dt_(max)↑,-dp/dt_(max)↑,t—dp/dt_(max)↓,V_(px)↑,V_(ce-cpip)↑,V_(max)↑;在麻醉开胸狗,除MAP降低和SV增加外,对其它指标的作用方向与心肺制备实验结果基本一致;两个实验中测取的Lissajous图形的正向前降支均向右上方移位。从而排除了前、后负荷的影响,说明泵功能的改善似由于细辛增强心肌收缩性能所致。通过细辛与去甲乌药硷、异丙肾上腺素的比较研究,提示三者的作用基本相似,唯SV显示不同的结果。细辛使SV增加,去甲乌药硷、异丙肾上腺素却使SV减少,这可能与细辛增加HR的比率较二者为低密切相关。肾上腺素能β受体阻滞后,细辛增加CO的作用仍然存在,值得进一步研究。&nbsp&&&&&相关查询
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R977.6黄芪多糖(astragalus polysaccharide,APS)是补气中药黄芪的有效成分之一。具有免疫调节、抗氧化、抗肿瘤等多种生物活性[1-3]。研究发现,APS具有明显的心血管保护效应。APS经口服给药后对糖尿病心肌病及心肌肥厚等都有一定的改善作用[4]。我们最近的研究证实,APS抗肥厚的机制与其对细胞内Ca2+超载的抑制作用有关[5]。但对其抑制Ca2+超载的机制尚不明确。研究发现黄芪注射液可明显抑制肌质网/内质网Ca2+-ATP酶2a(sarco/en-doplasmic reticulum 2a,SERCA2a)的表达[6],APS对糖尿病心肌病心脏SERCA2a表达也呈现明显抑制效应[7],于是,我们推测APS的抗心肌细胞Ca2+超载效应可能与其抑制SERCA 2a的表达有关。本研究将探讨APS对SERCA2a表达及活性的影响。1材料与方法1.1实验动物出生1~3 d的Sprague-Dawley(...&
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权威出处：
缺氧和长期炎症造成肺损伤会导致肺纤维化(pulmonaryfibrosis),临床上多种慢性肺部损害由于在肺血管周围发展肺纤维化,形成肺动脉高压。肺动脉高压的病因很多,其中肺纤维化是形成肺动脉高压的重要致病机理。肺动脉高压的机制复杂,其中许多继发于血管胶原性疾病,临床治疗效果差。近年研究表明,肺动脉高压的肺组织中内皮素(en-dothelin)增多,与形成肺损伤和形成肺纤维化密切相关,为新药研制带来新的希望。在特发性肺纤维化病人[1]和系统性硬化症病人[2]的血浆和肺灌洗液中,内皮素都明显升高。病人气道表面细胞和肺Ⅱ型细胞,都有增强的内皮素免疫组化染色,并与疾病进展相关。内皮素转基因小鼠,可见明显的肺纤维化病变[3]。博莱霉素(BLM)诱导肺组织炎症性损伤,长期病变可形成肺纤维化[4]。BLM诱导的肺损伤和肺纤维化,胶原蛋白含量增加,与肺内内皮素升高相关,可模拟胶原性疾病引起肺动脉高压的模型。ParkSH[5]等发现,内皮素受体...&
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